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of noncaloric artificial sweeteners {#sec1}
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Noncaloric artificial sweeteners (NASs), or “zero-calorie” food and beverage additives, are mainly designed to “artificially sweeten” foods by replacing the function of sugars by signaling their presence. NASs contain mainly acesulfame K (ASK), cyclamate, sucralose, and aspartame or rely on similar mechanisms of the bitter taste to evoke sweet sensations in consumers. Several experimental studies in rodents showed that long-term consumption of NASs induces metabolic syndromes such as hyperleptinemia, reduced insulin sensitivity, and altered body weight regulation, which ultimately lead to obesity \[for review see Ref. ([@B1])\]. In humans, one group-level observational study reported that ASK and the nonnutritive artificial sweetener saccharin contribute to increased body weight and are indicators of obesity \[for review see Ref. ([@B2])\]. Yet, the impact of NAS consumption on obesity is still the subject of heated debate. For example, a recent study showed that NAS use was associated with a decreased risk of obesity at different BMI levels in an observational study ([@B3]), though another study detected no effect of NAS use on body weight or adiposity ([@B4]). Hence, the literature is ambiguous regarding the effects of NAS consumption on body weight and the metabolism. In that context, we examined the effects of NAS intake on body fat distribution and the regulation of energy storage in human adipose tissue.

Different NASs have different physiological effects. The NAS used in our study was ASK, acesulfame potassium, with the CAS registry number 1863-55-6. In our previous studies, which are briefly outlined below, we studied the effects of ASK consumption on hunger, energy intake, and blood metabolite levels in healthy young men ([@B5], [@B6]). For these studies, detailed information about the study protocol was published in previous studies \[for review see Ref. ([@B7])\]. In the first study, the effect of an acute dose on appetite regulation was tested by providing participants with either ASK or a placebo drink 30 min before their overnight fasted evening meal for 2 d ([@B5]). A reduction in hunger was observed with the ASK consumption ([@B5]). In the second study, our findings indicated that chronic consumption of ASK had no significant effect on blood metabol

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In this mysterious post-apocalyptic city, Max Weber’s image-infused television broadcasts appear to be the pinnacle of human civilization. However, a series of mysterious events takes place that start to threaten to destroy it. Is it Max’s imagination? Or is it that his long-awaited sporting event, the Climax, truly was nothing more than a nightmare? And what exactly are the G-Rangers?

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